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This process involves trafficking of L2/vDNA from endolysosomal compartments to the trans -Golgi where upon mitosis post-Golgi vesicle-bound L2/vDNA tethers to mitotic chromosomes for nuclear localization and ultimately penetrates the limiting membrane to gain access to transcriptional machinery [26,27,65]

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The NF-B family includes five members, with the RelA/p50 heterodimer driving transcription in the canonical pathway (Oeckinghaus and Ghosh, 2009)

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